Bile salts in pregnancy?


Question by: Giorgio Rinaldi | Last updated: December 29, 2021

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What is intrahepatic cholestasis of pregnancy and what is its incidence? It is a pathological condition that involves an accumulation of bile salts in the liver and in most cases occurs at the end of the second or early third trimester of pregnancy (although it can appear even earlier).

How to lower bile acids?

Bile acid sequestering resins are drugs used to reduce blood cholesterol levels.

Among the resins sequestering bile acids the following drugs are mentioned:

  1. Cholestyramine (Questran)
  2. Colestipol (Colestid)
  3. Colesevelam (Cholestagel)

What do high bile acids involve in pregnancy?

These include: increased risk of fetal prematurity, death at birth and respiratory distress syndrome. The management of gravidic cholestasis involves the intake of drugs useful to avoid the accumulation of bile acids in the bloodstream and the induction of childbirth.

What to do in case of pregnancy cholestasis?

Cholestasis of pregnancy, caused by an impaired breakdown of bile acids in the liver, is not considered a serious problem for the expectant mother. Standard therapy is based on ursodeoxycholic acid, a drug that can also be used at high doses: without particular contraindications for the fetus.

What does bile acids mean?

Bile acids are detergent substances, that is, capable of dispersing water-insoluble lipids in aqueous solution. For this reason, bile acids play a leading role in the digestion and absorption processes of lipids.

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What does it mean to have high bile acids?

An increase in the amount of circulating bile acids measured in the fasted condition is indicative of the liver’s inability to extract them from the blood, a situation typically occurring in liver and gallbladder disease.

Why do bile acids rise?

The level of bile salts represents a parameter of hepatocyte function. Their increase may be due to cholestasis, hepatitis A, hepatitis B, infectious mononucleosis, chronic hepatitis, drug-induced liver disease, primary biliary cirrhosis.

How to notice pregnancy cholestasis?

The hallmarks of cholestasis gravidarum include the following symptoms:

  1. Most common: itching, particularly (but not limited to) the palms of the hands and soles of the feet, without the presence of a rash; itching that increases in the evening; …
  2. Less common: darker urine; clear stools;

What to eat to lower bile acids?

The protective role of fruit and vegetables could primarily be linked to vegetable oils. Furthermore, a diet rich in fiber and calcium would reduce the amount of hydrophobic bile acids.

How to lower bile acids naturally?

Mint in case of biliary colic

Peppermint is the main remedy in case of biliary colic, in particular the intake of essential oil seems to be the most indicated. It is able to dissolve the bile avoiding the formation of stones.

How to cleanse the liver in pregnancy?

Liver-friendly vegetables are those with a bitter taste such as endive, dandelion, chicory, thistle and artichoke. The latter in particular will have a restorative action on the liver cell.

What is a cholestasis?

Cholestasis is the reduction or stopping of bile flow. Bile is a digestive fluid produced by the liver. Disorders affecting the liver, bile ducts or pancreas can induce cholestasis.

How Much Should the Bile Acids Be?

The normal values ​​that an adult must have in a blood test should not exceed 8 units per cubic millimeter of blood.

How is cholestasis treated?

As mentioned, cholestyramine (Questran ®) is the first-line drug used to treat the annoying itchy skin that occurs in patients with cholestasis. Cholestyramine is a drug available for oral administration in the form of a powder for oral suspension.

What not to eat with high bile acids?

Gallstones: What Not to Eat

  • Eggs, especially the yolk.
  • Spirits.
  • Whole milk and derivatives.
  • Cream.
  • Fried (cutlets, omelettes, croquettes etc.)
  • Fatty meat.
  • Crustaceans, mussels and clams.
  • Sausages.

How to dissolve the stones in the choledochus?

The endoscopic approach involves the execution, in hospitalization, of an Endoscopic Retrograde Cholangio-Pancreatography (ERCP), a procedure that through the use of a particular endscope allows to reach the outlet of the choledochus in the duodenum and to remove the stones present.

How to cleanse the gallbladder naturally?

To start, you need to take a tablespoon of extra virgin olive oil mixed with a teaspoon of lemon juice on an empty stomach. In fact, the combination of these two substances stimulates the gallbladder and helps eliminate all waste accumulated in it.

When is Deursil taken?

The administration of DEURSIL RR should be carried out in a single evening intake, preferably at bedtime. There is no treatment for pediatric patients.

How do you know if you have a poisoned liver?

more information ranges from general ones (such as fatigue, general malaise, nausea, itching, loss of appetite) to more severe symptoms (such as jaundice, liver enlargement, pain in the upper right abdomen, confusion, disorientation and decrease in the state of vigilance).

How do bile salts work?

Bile salts (consisting of complex acids, having a chemical structure similar to cholesterol, and salified by strong bases), play an essential role in the absorption of fats, in fact, they act as powerful emulsifying agents, favoring the minute subdivision of fats, so that these are more …

What happens if the bile gets around?

The excessive presence of bile irritates and inflames the gastric and esophageal mucous membranes. The main symptoms that follow are pain in the upper abdomen, heartburn and vomiting containing a yellow-green substance. For a correct diagnosis, several tests are required, including gastroscopy.

What organ produces bile?

In the liver, bile drains from the intrahepatic collecting system into the right and left hepatic ducts, which join in the common hepatic duct. When fasted, approximately 75% of the bile produced passes from the common hepatic duct into the gallbladder through the cystic duct.

Which marker is mainly used for cholestasis?

Alkaline phosphatase (ALP) – Alkaline phosphatase (ALP) is a hepatic marker found in the blood that shows how well the bile ducts in the liver work and can be used to monitor response to therapy.

How to relieve the liver?

A classic remedy for detoxifying the liver is to drink warm-warm water and lemon in the morning, at least 15 minutes before breakfast. Other natural remedies can be Aloe vera juice or birch sap, both to be taken in the morning on an empty stomach and in the evening before going to bed.

What to do to cleanse the liver?

Among the most suitable foods to purify the liver and stimulate its functionality we remember:

  1. Lemon juice: rich in ascorbic acid (vitamin C), it effectively cleanses the liver, but can cause some problems for those suffering from gastritis;
  2. Artichoke;
  3. Milk thistle;
  4. Apple;
  5. Blueberry;
  6. Cabbage;
  7. Pollen;
  8. Acerola;


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