Does melanoma in situ relapse?


Question by: Brigitta Silvestri | Last updated: August 5, 2021

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Medium risk: the risk of recurrence ranges from 20% to 50%. High risk: the risk of recurrence is greater than 50%. High-risk melanoma has a high probability of already having spread to local or distal sites by the time of treatment.

What is melanoma in situ?

In stage 0 melanoma, the malignancy is still confined to the upper layers of the skin. This means that the cancer cells are only in the outermost layer of the skin and have not spread deeper. The term for this type of tumor is “in situ”, which means “in the place” in Latin.

What to do after the removal of a melanoma?


For AI melanomas: clinical control 6/12 months for 5 years, annually after the 5th year (at the discretion of the specialist). Dermatological visit every 6/12 months based on the patient’s characteristics. Ultrasound at the lymph node stations (at each checkup).

How long does it take for a melanoma to come?

In elderly people, melanoma develops quite often on the face, in a flat form, and evolves very slowly, extending for a long time only superficially until it assumes considerable size over many years (patches or plaques of an inhomogeneous brown color with an uneven appearance map).

What are the symptoms of a melanoma?

Melanoma has no symptoms: it just writes its message on the skin and must be recognized. The only symptoms that may be associated with the advanced stage of the disease are itching, serum secretion or bleeding, but they are not present in all cases.

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What can cause a melanoma?

Causes. At the origin of melanoma there is a malignant degeneration of melanocytes, the cells that produce melanin, essential for defending the skin from solar radiation.

How to cure melanoma?


  1. Surgery. Almost all melanomas are surgically removed, limited to the cancerous mole or a portion of the surrounding area, based on the extent of tumor formation. …
  2. Radiotherapy. …
  3. Immunotherapy. …
  4. Risk factors. …
  5. Prevention.

How does a melanoma evolve?

Melanoma develops in successive times through various stages of progression in which it presents different clinical and histological aspects. The first three lesions begin with a ‘flat’ spread over the skin surface, representing the horizontal growth phase (flat melanoma).

How does melanoma develop?

Melanoma is formed when a genetic error occurs in the cells that produce melanin, that is, the melanocytes.

How to recognize a nodular melanoma?

What Features To Pay Attention To?

  1. Dome shape with generally regular edges;
  2. Black or dark blue, brown or reddish-pink color;
  3. Hard consistency;
  4. Very fast development and growth;
  5. Tendency to remain on the skin and not regress in a few days as can happen, however, for pimples and boils.

How does melanoma metastasize?

M1a: The tumor has metastasized to the skin and distal sites, subcutaneous layer or distal lymph nodes. The LDH level is normal. M1c: Tumor metastases are also present in other organs besides the lungs and the LDH level is normal.

How many stages of melanoma are there?

Evolution. Cutaneous melanomas are generally classified into four stages (I to IV, while stage 0 indicates melanoma in situ, affecting only the upper layer of the skin) defined on the basis of the TNM system.

What are the metastases of melanoma?

Melanoma can spread to almost the entire body, however the most frequent localizations of metastases are the lymph nodes, lungs, liver, bones, brain. The symptoms change depending on the affected organ.

When is melanoma dangerous?

Melanoma is always potentially dangerous, if it is not identified and removed, because it can affect other organs. This is why it is important to undergo an annual dermatological examination and pay attention if you notice a new mole with particular characteristics or an old mole that changes shape.

What is the difference between carcinoma and melanoma?

Basal and squamous cell carcinomas, unlike other skin cancers such as melanoma, metastasize only in rare cases and many years after their appearance. As a result, they are usually removed when they are still localized.

What does skin melanoma look like?

Types of melanoma

lentigo maligna (melanoma in situ) is a slowly evolving lesion that manifests itself as a flat, non-palpable, brown, very smooth spot, with loss of the normal skin profile. It generally has a slow growth rate (years) and rarely spreads to other parts of the body.

How to distinguish a benign mole from a malignant one?

In a benign mole, on the other hand, a uniform and symmetrical (or almost) growth is noted. B as Edges: irregular and jagged edges are a wake-up call. A benign lesion has defined and very regular edges; on the contrary, a malignant nevus has discontinuous and totally irregular margins.

How can melanoma be prevented?

The rules of prevention of melanoma

  1. exposure to the sun moderately from an early age, especially avoiding the hottest hours and possible sunburn;
  2. in the sun it is advisable to wear hats and sunglasses, and above all protective creams suitable for your phototype;

How come the moles increase?

They are benign formations, and the increase in their number or size is a natural phenomenon. On the other hand, a medical check-up is necessary when the presence of a melanoma (malignant tumor) is suspected, which is instead a degeneration of melanocytes.


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