What is anticoagulants for?


Question by: Dr. Maria Longo | Last updated: January 3, 2022

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Anticoagulants are drugs that help prevent clots from forming inside blood vessels (veins and arteries).

What is anticoagulant used for?

Introduction. Anticoagulant drugs are drugs capable of hindering blood clotting. Given their therapeutic action, these drugs are used to prevent the formation of thrombus and to hinder the growth of those that have already formed.

What are anticoagulant drugs?

The new oral anticoagulants (NAOs) are a class of drugs indicated for the prevention of stroke, embolism and AF. They act on the X factor of the coagulation cascade. The molecules currently in use in Italy are: rivaroxaban, apixaban and dabigatran.

What drugs thin the blood?

Warfarin – the active ingredient of the registered specialty Coumadin ® – is an oral anticoagulant drug taken to “thin the blood” and prevent clots from forming within the circulation.

What is the best anticoagulant?

In this analysis, published in Lancet Haematology, the anticoagulant edoxaban was shown to be just as effective and safer than warfarin in long-term treatment.

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What is the name of the new drug that replaces Coumadin?

In Italy there are currently three drugs for oral use that can perfectly replace Coumadin (trade names Pradaxa, Eliquis, Xarelto). The drugs are distinguished by mode of action, but the indications, results and costs are very similar.

Who prescribes the anticoagulant?

NAO / DOAC oral anticoagulants: the GP can prescribe them.

What can anticoagulants cause?

Oral anticoagulants, like all medicines, can cause unwanted (side) effects. Since anticoagulants delay the normal blood clotting process, the most common side effect is excessive bleeding (haemorrhage).

How to calculate the dosage of Coumadin?

It is recommended that Coumadin therapy be initiated using doses of 2.5 to 5 mg per day for 2-4 days. Thereafter, 1 to 10 mg per day are administered based on INR values. For most therapeutic indications the optimal INR is between 2 and 3.

How is blood clotting treated?

If a person already has a blood clot, a thrombolytic (fibrinolytic) drug can be given to help dissolve it. Thrombolytic drugs, such as streptokinase and tissue plasminogen activators, are often used to treat heart attacks and strokes due to blood clots.

What does NAO therapy mean?

The NAO or New Oral Anticoagulants are a group of active ingredients with an anticoagulant action that is exercised directly. For this reason, they are also known as Direct acting Oral AntiCoagulants or DOACs.

What not to take with blood thinners?

It is necessary to strictly follow the prescriptions in the assumption of the daily dose of oral anticoagulant and to report punctually to the INR control.

Avoid completely:

  • Cauliflower.
  • Broccoli and Brussels sprouts.
  • Turnip greens.
  • Lettuce.
  • Parsley.
  • Savoy cabbage.
  • Asparagus.
  • Tomatoes (only tomato sauce is allowed)

When to take the anticoagulant?

Anticoagulant therapy is generally indicated in all those patients who are at risk of forming thrombi or clots, due to a pre-existing pathology (for example atrial fibrillation) or the momentary clinical conditions in which they find themselves (for example a fracture of the femur).

What not to eat if you take Coumadin?

What Foods To Avoid

  • cabbage and parsley (to be avoided or eaten in particularly modest quantities);
  • broccoli, sprouts, cabbage, spinach, radicchio, turnip greens, sprouts, lettuce (avoid quantities exceeding 100 grams);

What to do if the INR is high?

The finding of a high INR indicates that the blood tends to clot more slowly, therefore the patient is more exposed to the risk of bleeding. If so, it may be necessary to decrease the dose of the anticoagulant drug being used.

What to do if INR is high?

When the INR is particularly high (> 5) the doctor may recommend, in addition to the drug suspension, the intake of vitamin K orally or intravenously (in the most severe cases) to accelerate the return to the desired values.

When the blood is too liquid, what does it depend on?

Little control, increased risk. Strokes and bleeding are lurking for too many patients who are unwilling to monitor themselves and / or neglect oral anticoagulant therapy.

What are Vitamin K Antagonists?

The anticoagulant drugs antagonists of vitamin K (AVK) are divided into: coumarins: warfarin (Coumadin®); acenocoumarol (Sintrom®); phenprocoumon (the latter not available in Italy) indandionics (used in France)

Who can prescribe DOACs?

Therefore, medical specialists and general practitioners will be able to continue prescribing the new direct-acting oral anticoagulants (NAO / DOAC: apixaban, dabigatran, edoxaban, rivaroxaban) and vitamin K antagonists (AVK: warfarin and acenocoumarol) in patients with FANV according to the envisaged procedures …

Who can prescribe Lixiana?

Currently, the first prescription of NAOs (Dabigatran-Pradaxa, Rivaroxaban-Xarelto, Apixaban-Eliquis, Edoxaban-Lixiana) is carried out by specialists operating in authorized hospital centers indicated by the Regions and identified by the Health Management of the individual structures (cardiologist, internist,. ..

Who can draw up the treatment plan?

The Treatment Plan, the Prescription Card and the Treatment Plan Card must be completed by a physician specializing in the medical discipline relevant to the pathology to be treated. The specialist doctor must be authorized by the Region or the Autonomous Province.

Who can prescribe the Nao?

WHO CAN PRESCRIBE NAO AND WITH WHAT PROCEDURE? Prescribing by the National Health Service is only possible by some specialists (neurologist, cardiologist, geriatrician, hematologist who works in thrombosis and haemostasis centers, internist).

How to switch from heparin to Nao?

In the case of switching from low molecular weight heparin (LMWH) and fondaparinux to NAOs, these should be administered 2 hours before the last scheduled dose of LMWH, while in the reverse transition the EBPM should be administered at least 24 hours after the last dose of the NAO.

What happens if anticoagulant is stopped?

“No matter which drug they are treated with, patients who need anticoagulation therapy return to have an intrinsic risk of stroke and embolism if they stop it, which, therefore, should not be done lightly” said the first author of the analysis. Manesh Patel, of Duke University in Durham.

Which anti-inflammatories can be taken with anticoagulants?

Some of these drugs increase and others decrease the effectiveness of anticoagulant therapy. In case of fever or pain, without abusing them, the best drug is IBUPROFENE (moment, antalgil, brufen).


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